Review Article
The efficacy of bedaquiline versus kanamycin in multi-drug resistant tuberculosis: A systematic scoping review
Submitted: 31 May 2021 | Published: 29 November 2021
About the author(s)
Lisa Singh, Discipline of Pharmaceutical Sciences, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South AfricaLehlohonolo J. Mathibe, Division of Pharmacology (Therapeutics), Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Varsha Bangalee, Discipline of Pharmaceutical Sciences, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Abstract
Background: Drug-resistant tuberculosis (DR-TB) has become a serious cause of concern both on a global scale and in South Africa. It is associated with a lower successful treatment rate, thus creating a hurdle in achieving good treatment outcomes for patients.
Aim: The aim of this study was to compare the efficacy of the drug kanamycin, an injectable aminoglycoside, to bedaquiline, a newer oral drug used to treat DR-TB.
Methods: PubMed and Google Scholar, both of which are online databases, were extensively searched using the necessary keywords so that studies that were relevant to the scoping review were retrieved. A data-charting list was developed to extract the needed data for this scoping review.
Results: The main findings of the scoping review showed that bedaquiline was highly efficacious in the treatment of DR-TB, and that it was a valuable addition in the treatment of DR-TB. The findings of the study also showed that kanamycin does not have good efficacy against DR-TB. and its use extends the treatment of DR˗TB.
Conclusion: It stands to reason that bedaquiline replaces kanamycin in the DR-TB drug regimen as it was shown to be more efficacious and patients experienced better treatment outcomes in a shorter period of time. There were also fewer adverse effects associated with bedaquiline as compared to kanamycin.
Contribution: Bedaquiline-based DR-TB therapy is more efficacious than aminoglycoside-based regimens which include kanamycin.
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Crossref Citations
1. Bedaquiline Effect Towards QT Interval in Drug Resistant Tuberculosis (DR-TB): A Systematic Review
Arya Marganda Simanjuntak, Rahmadini Aulia, Dhewa Triguna Banjarnahor, Riski Dimas Harianja, Indra Yovi
Siriraj Medical Journal vol: 75 issue: 9 first page: 638 year: 2023
doi: 10.33192/smj.v75i9.263683